Storia do Mogor, or Mogul India, 1653-1708

Op-brai130095 1708..1717

Beta-propeller protein-associated neurodegeneration: a new X-linked dominant disorder with brain iron accumulation Susan J. Hayflick, Michael C. Kruer, Allison Gregory, Tobias B. Haack, Manju A. Kurian, Henry H. Houlden, James Anderson, Nathalie Boddaert, Lynn Sanford, Sami I. Harik, Vasuki H. Dandu, Nardo Nardocci, Giovanna Zorzi, Todd Dunaway, Mark Tarnopolsky, Steven Skinner, Kenton R. Holde...

Dmd059139 1708..1718

The human pregnane X receptor (hPXR) is recognized as a xenobioticsensing nuclear receptor that transcriptionally regulates the gene expression of drug-metabolizing enzymes and transporters. Our study elucidates the mechanism by which the localization of hPXR is regulated through threonine-290. A phosphomimetic mutation at threonine-290 (T290D) retained hPXR in the cytoplasm of HepG2, HuH6, and...

Pii: S0309-1708(98)00025-6

Accurate characterization and modeling of subsurface flow in multi-fluid soil systems require development of a rapid, reproducible experimental method that yields the information necessary to determine the parameters of the capillary pressure–saturation and permeability functions. Previous work has demonstrated that parameter optimization using inverse modeling is a powerful approach to indirec...

Edward Tyson, M.D., F.R.S., 1650–1708

Performance of electrophysiologic study in an asymptomatic patient with type 2 intermittent Brugada syndrome: To do or not to do?

Background: Brugada syndrome (BrS) is an inherited channelopathy, which is associated with sudden cardiac death due to rapid polymorphic VT or VF. There is no definite consensus regarding the management of asymptomatic patients. Some experts advocate close follow-up; others propose the programmed stimulation for risk stratification. We aimed to evaluate the benefit of complete atrial and ventri...